I'm a big believer in open science -- see this great polemic over at Mendeley for a good read -- but it's always interesting to think about how such things as "data release" can be perverted by clever scientists. I'm currently in France working on some ascidians with Billie Swalla -- more on …
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(This project is a collaboration with Jason Pell and Adina Howe)
A few weeks ago I posted about a k-mer filtering approach that we were using to remove low-abundance k-mers from metagenomic data sets, prior to assembly. This technique is working well, and we've managed to do some assembly of …
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The Terabase Metagenomics meeting was good fun, but I most valued the computational component (because that's what I do). Rachel Mackelprang and Rob Knight and I wrote down a list of the computational issues involved in a petabase metagenomics project, and that list will help direct my future research. I'll …
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I'm on my way back from the Terabase Metagenomics meeting in Snowbird, UT, and I'm buzzing with ideas about how to move forward in metagenomics and bioinformatics research. Metagenomics, the use of genomics approaches to study microbial communities, has been opening up as sequencing drops in price. With sequencing becoming …
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I've spent the last few weeks working on a simple solution to a challenging problem in DNA sequence assembly, and I think we've got a nice simple theoretical solution with an actual implementation. I'd be interested in comments!
Briefly, the algorithmic challenge is this:
We have a bunch of …
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After my recent next-gen sequencing course, which was supposed to tie into the whole software carpentry (SWC) effort but didn't really succeed in doing so the first time through, I started thinking about the Right Way to tie in the SWC material. In particular, how do you both motivate scientists …
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So, I'm running this summer course and I am trying to figure out how to organize the notes for students. I'd like to mix curriculum-specific notes ("here's what we're doing today, and here are some problems to work on") with tutorials (material independent of a single course, like "here's how …
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