1. A memory efficient way to remove low-abundance k-mers from large (metagenomic?) DNA data sets

    I've spent the last few weeks working on a simple solution to a challenging problem in DNA sequence assembly, and I think we've got a nice simple theoretical solution with an actual implementation. I'd be interested in comments!

    Introduction

    Briefly, the algorithmic challenge is this:

    We have a bunch of …

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  2. Teaching next-gen sequencing data analysis to biologists

    Our sequencing analysis course ended last Friday, with an overwhelmingly positive response from the students. The few negative comments that I got were largely about organizational issues, and could be reshaped as suggestions for next time rather than as condemnations of this year's course.

    The 23 students -- most with no …

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  3. Running a next-gen sequence analysis course using Amazon Web Services

    So, I've been teaching a course on next-generation sequence analysis for the last week, and one of the issues I had to deal with before I proposed the course was how to deal with the volume of data and the required computation.

    You see, next-generation sequence analysis involves analyzing not …

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