I've been doing some more focused bioinformatics programming recently, and as I'm thinking about how to teach biologists about data analysis, I realize more and more how much backstory goes into even relatively simple programming.
The problem: given a reference genome, and a very large set of short, error-prone, random …
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These days, molecular biologists are dealing with lots and lots of sequences, largely due to next-gen sequencing technologies. For example, the Illumina GA2 is producing 100-200 million DNA sequences, each of 75-125 bases, per run; that works out to 20 gb of sequence data per run, not counting metadata such …
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Analyzing Next-Generation Sequencing Data
May 31 - June 11th, 2010
Kellogg Biological Station, Michigan State University
CSE 891 s431 / MMG 890 s433, 2 cr
Applications are due by midnight EST, April 9th, 2010.
Course sponsor: Gene Expression in Disease and Development Focus Group at Michigan State University.
Instructors: Dr. C. Titus …
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OK, so you have a genome -- let's say it's about 1gb in size -- and you want to do ChIP-seq on a transcription factor that you think binds ~1000 places in the genome. You've measured the specificity of the transcription factor and it seems to enrich about 10-fold over background (an …
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Just submitted this on Thursday:
Next generation sequencers are beginning to impact agricultural biology. Over the next few years, next generation sequencing will produce incredibly large datasets that will address structural (e.g., SNPs, CNVs, indels, methylation, translocations) and functional (e.g., RNA expression, transcription factor binding sites) variation in …read more
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The decision of python-dev to deprecate bsddb has left us in a bit of a pickle (hah!) over in the pygr project. We're looking for a replacement for bsddb for default storage of infrequently- (or never-) changed pickled Python objects. Some of the parameters under consideration are:
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- Python version availability …
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The latest hot shit idea for making a protein-protein interaction database leaves me lukewarm.
A few months ago I met with a genomics group, and we had a back-and-forth about genome annotation. The conversation went something like this:
them: "We have to improve the tools for annotating un-annotated genes!" me …read more
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