1. Our approach to replication in computational science

    I'm pretty proud of our most recently posted paper, which is on a sequence analysis concept we call digital normalization. I think the paper is pretty kick-ass, but so is the way in which we're approaching replication. This blog post is about the latter.

    (Quick note re "replication" vs "reproduction …

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  2. Paper draft: Scaling metagenome sequence assembly with probabilistic de Bruijn graphs

    (updated to point to http://arxiv.org/).

    Authors: Jason Pell, Arend Hintze, Rosangela Canino-Koning, Adina Howe, James M. Tiedje, C. Titus Brown

    Abstract:

    The memory requirements for de novo assembly of short-read shotgun sequencing data from complex microbial populations are an increasingly large practical barrier to environmental studies. Here we …
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  3. Data Intensive Science, and Workflows

    I'm writing this on my way back from Stockholm, where I attended a workshop on the 4th Paradigm. This is the idea (so named by Jim Gray, I gather?) that data-intensive science is a distinct paradigm from the first three paradigms of scientific investigation -- theory, experiment, and simulation. I was …

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