I finally got sick of manually schlepping BLAST files around, so I wrote something to do it for me. 'zounds' is a very simple server/client system for coordinating a bunch of 'worker' nodes through a central server; it does everything in Python with objects and pickling, so it's easy to do extra Python-based processing on the worker nodes. See 'filters' for more info.
You can read a bit more about zounds here:
It's freely available, open-source, etc. etc.
Comments and thoughts welcome; send them to the bip list.